400 Main Street is home to Weston's oldest building on Main Street - and the newest building on Main Street.

1839: The original building was the first built on Main in Weston, Missouri making 400 Main Street home to the footprint of Weston's first retail establishment.

1850: Warner and Hart advertised Cheap goods for sale

Buffalo Bill Cody's Uncle, Elijah Cody, owned the building and ran Cody's Hemp House. The tin work on the building was the first tin work done in Weston. Major David Holladay and Mr. Theodore Warner bought out Cody and soon changed it to The Gallon House selling whiskey by the gallon.

1888: Major D. Holladay had the building repaired and continued in the wholesale liquor business. The building late became a warehouse owned by Mr. A.P. Doppler

1910: The old wooden building was removed and the present building was built by A.P. Doppler

Doppler operated a dry goods store and later a grocery store. He also sold Queensware.

1928: Lee Page opened a full service "strictly cash" grocery store.

1932: C. H. Porter store opened a dry goods store

1940s: G. A. How operated a boot & shoe store after moving here sometime after WWII and left in 1964

1970s B&B Appliance

1973-1979 Western Auto Store

1977-1988 The Overflow, live music, pizza & sandwiches

1990-1999 Tobacco Road Antiques

1992 The Doppler Mercantile, name in honor of the original owner of the building

2010 Cactus Creek, owned by Tracy Taylor Smith ("Fancy") opened a retail boutique with clothes, home goods & antiques.